8–12 Jul 2025
Politechnica Univ
Europe/Bucharest timezone

Development of an ultra-high dose rate proton irradiation system for radiobiology studies at a 3 MV TandetronTM

9 Jul 2025, 12:30
15m
Politechnica Univ

Politechnica Univ

Splaiul Independenței 313, București 060042
Oral Presentations S02 – Biophysics, Life Sciences, Medical Physics Biophysics, Life Sciences, Medical Physics

Speaker

Mr Andrei-Theodor Hotnog (Horia Hulubei National Institute for Physics and Nuclear Engineering)

Description

Small accelerators are capable of delivering ultra-high dose rates (UHDR) during proton irradiation, which makes them valuable tools in the development of FLASH radiotherapy. However, achieving accurate in-air irradiation at such dose rates demands exceptionally precise beam characterization. This work describes the way we addressed the challenge of accurate dosimetry while developing a new beamline at the 3 MV Tandetron™ from IFIN-HH, specifically in the context of radiobiology studies. We outline the beamline’s design, construction, and calibration, emphasizing its critical components. Computational work, in the form of FLUKA simulations, blends seamlessly with experiments carried out during the commissioning process. Predicted high spatial precision in dose deposition has been validated through radiochromic film analysis. Accurate dose delivery over time is ensured by stringent regulation of both irradiation duration and dose rate, which we have measured comparatively using a Faraday cup and an Advanced Markus ionization chamber. Finally, we introduce a custom-designed sample holding and manipulation device that significantly improves irradiation efficiency and enhances experimental throughput.

Primary author

Mr Andrei-Theodor Hotnog (Horia Hulubei National Institute for Physics and Nuclear Engineering)

Co-authors

Decebal Iancu (Applied Nuclear Physics Department, Horia Hulubei National Institute for Physics and Nuclear Engineering, Măgurele, Romania) M. Lechintan (Applied Nuclear Physics Department, Horia Hulubei National Institute for Physics and Nuclear Engineering, Măgurele, Romania) Mihai Radu (Department of Life and Environmental Physics, Horia Hulubei National Institute for Physics and Nuclear Engineering, Măgurele, Romania) Mihai Straticiuc (Applied Nuclear Physics Department, Horia Hulubei National Institute for Physics and Nuclear Engineering, Măgurele, Romania) Radu Andrei (Applied Nuclear Physics Department, Horia Hulubei National Institute for Physics and Nuclear Engineering, Măgurele, Romania)

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