The unique physical characteristics of hadron therapyโmost notably the Bragg peak phenomenonโfacilitate highly precise dose deposition that effectively targets tumors while minimizing radiation exposure to adjacent healthy tissues. The advancement of hadron therapy requires thorough research in radiobiology to better understand the complex effects that high doses of charged particles exert on...
We performed voltage-clamp experiments on outside-out patches excised from HEK293 cells stably expressing hNav1.5. Upon 3-min exposure to a 808.5 nm laser the peak Na+ current amplitude remained steady (96.64ยฑ5.25% of initial values) while in control conditions it decreased (37.95ยฑ9.14%); in whole-cell experiments relative amplitudes were 111.2ยฑ47.0% (laser) vs. 70.6ยฑ33.0% (control). We also...
Small accelerators are capable of delivering ultra-high dose rates (UHDR) during proton irradiation, which makes them valuable tools in the development of FLASH radiotherapy. However, achieving accurate in-air irradiation at such dose rates demands exceptionally precise beam characterization. This work describes the way we addressed the challenge of accurate dosimetry while developing a new...
The blood-brain barrier (BBB) structure is essential for maintaining brain homeostasis by regulating the fluid and substances transport between the bloodstream and central nervous system, while protecting against toxins and pathogens. Disruption of BBB integrity is associated with neurodegenerative diseases like Alzheimerโs and Parkinsonโs, in which factors such as inflammation and amyloid-ฮฒ...
We present a novel, integrated platform for high-resolution single-cell biophysical characterization that combines dielectrophoresis (DEP) and optical tweezers (OT) within a single, synchronized experimental setup. This dual-modality system enables simultaneous, real-time extraction of both electrical and optical properties from individual, living cells in suspensionโwithout the need for...
PURPOSE:
In many institutions, tumors, and organs at risk contours are delineated manually; this is also costly and time-consuming. Recently, various automatic contouring methods have been developed to address these problems. However, these methods may not provide accurate contours for the physicians. One of the reasons is that most autocontouring algorithm results have been produced on CT...
Purpose Gamma index analysis and equipment are the most commonly used
methods and equipment for dosimetric control. Gamma index analysis is influenced
by multiple factors, and its accuracy is contingent upon various parameters and
variables. However, there has been limited research on how variations or errors in
dose delivery impact the results of gamma analysis, especially when conducted...
This paper presents the decommissioning process of a diagnostic and therapeutic nuclear medicine department located within โMother Theresaโ University Hospital. This department, operated for more than 25 years and served as the sole public provider of nuclear medicine services in the country, using radiopharmaceuticals based on iodine-131 and technetium-99m. Following the relocation of all...
Early detection of breast cancer remains a crucial objective in modern medicine. High-sensitive X-ray imaging based on Talbot-Lau interferometry offers enhanced soft-tissue contrast compared to conventional mammography, making it a promising tool for non-invasive diagnostics. This work explores the integration of Convolutional Neural Networks (CNNs) with high-sensitivity Talbot-Lau imaging to...
The development of efficient drug delivery systems is important in modern medicine to improve therapeutic efficacy while minimizing side effects. Among various nanocarriers, mesoporous silica nanoparticles (MSNs) have emerged as versatile platforms due to their high surface area, tunable pore size, and capacity for surface modification. Surface functionalization of MSNs with targeting ligands,...
Radiation shielding is essential to reduce the biological, technological and environmental risks associated with radiation exposure. Recently, Digital Light Processing (DLP) 3D printing has gained increasing attention as a flexible and rapidly expanding additive manufacturing technique, offering the capability to produce customized, lightweight protective components using UV-curable resins...
This study focuses the retrospective analysis of the past 6 years of the occupational exposure at the Nuclear Medicine Department of the University Hospital Center โMother Terezaโ in Tirana (Albania). The effects of the relocation to a new building and the changes in the use of radiopharmaceuticals regarding radiological protection were analyzed. The personnel is monitored using chest badges...
Zinc phthalocyanine (ZnPc) derivatives have many interested
properties, such as high absorption capacity in the first
near-infrared region, good reactive oxygen species (ROS) generation
efficiency, and excellent photostability [1-3]. However, ZnPc are
highly hydrophobic and tend to aggregate, which decreases their
photosensitivity. Therefore, many attempts have been...
The increasing use of X-rays and gamma rays in medical applications has heightened the demand for effective radiation shielding materials to mitigate the harmful effects of ionizing radiation. While traditional lead aprons are effective in providing radiation protection, their significant weight and inflexibility, coupled with the toxicity of lead, pose considerable health risks. This study...
The T-number icosahedral configurations are considered to be given by a minimal mean-field thermodynamic model for the equilibrium structure of protein shells consisting of only pentamers and hexamers and correspond to the local free energy minima when the capsomers can switch freely between pentamer and hexamer.
Brome mosaic virus is one of the simplest and most thoroughly studied plant...
Interferometric X-ray imaging based on differential phase contrast offers greater sensitivity to soft tissue differences than conventional absorption-based radiography. This makes it a promising technique for the early detection of breast lesions, including those with minimal contrast, such as micro-calcifications. Additionally, since grating-based interferometry utilizes transmitted radiation...
Purpose
The integration of magnetic resonance imaging with linear accelerators (MR-Linac) has introduced a significant advancement in precision radiotherapy, especially for small field lung treatments where air-tissue interfaces present substantial dosimetric complexities. This study investigates the accuracy of dose calculation and delivery in ultrahypofractionated stereotactic body...
The growing threat of antibiotic resistance calls for effective alternatives. Antimicrobial peptides (AMPs) like temporin A and temporin F show promise due to their antiproliferative effects on microbial organisms and tumor cells [1,2]. As model systems for cellular membranes, lipid bilayers interact with specific AMPs, changing their mechanical characteristics and causing deterioration of...
